Publications – MCT Immortalized Hepatocytes Use of Immortalized Human Hepatocytes to Predict the Magnitude of Clinical Drug-Drug Interactions Caused by CYP3A4 Click here for more information Marc Vermeir, Pieter Annaert, Rao NVS Mamidi, Dirk Roymans, Willem Meuldermans & Geert Mannens: Cell-based models to study hepatic drug metabolism and enzyme induction in humans. Johnson & Johnson Pharmaceutical Research & Development, Preclinical Pharmacokinetics Click here to download PDF Dr. Amanda Ellis, Dr. Scott Grimm, Dr. Liyue Huang, Dr. Sara Otmani, Dr. Marie Ribadeneira and Dr. Diansong Zhou: Validation of Immortalized Human Hepatocytes as an Alternative Model for Induction Studies. 2005 AAPS Annual Meeting and Exposition 11/5/2005 - 11/10/2005. Click here for more information E. R. Jackson and D. E. Amacher: Alanine Aminotransferase Activity in the FA2N-4 Hepatocyte Clone. Click here to download PDF S. L. Ripp1, K. A. Trevena1, D. R. Gibbons2, 1 and J. B. Mills1: Use Of A Human Hepatocyte-Derived Cell Line To Simultaneously Assess CYP3A4 Induction And Time-Dependent Inhibition. Click here to download PDF Michael W. Sinz, Ph.D.: Drug-Drug Interactions: Inhibition and Induction Click here to download PDF Kevin C. Lyon, Maciej Czerwinski, Martin Perry, Paul Toren and Andrew Parkinson: Cytochrome P450 3A4 and 1a2 Induction in the Immortalized Hepatocyte Line, Fa2N-4, and Comparison With Primary Cultures of Human Hepatocytes. Click here to download PDF Florence Ndikum-Moffor, Maggie McMullen, Remi Gibson, Paul Toren, Cody Gartner, Jason Neat, Christa Linsenmeyer, Martin Perry, Maciej Czerwinski, Peter Opdam and Andrew Parkinson: Induction of UDP-Glucuronosyltransferases in Primary Cultures of Fresh and Immortalized Human Hepatocytes. Xenotech, 2004. Click here to download PDF Kevin C. Lyon, Maciej Czerwinski, Martin Perry, Paul Toren and Andrew Parkinson: Cytochrome P450 3A4 AND 1A2 Induction in the Immortalized Hepatocyte Line, Fa2N-4, and Comparison with Primary Cultures of Human Hepatocytes. Xenotech, 2004. Click here to download PDF A. David Rodrigues, Ph.D. Inhibition and Induction of Enzymes (Cytochromes P450): Rational Approaches to Anticipate and Minimize Drug-Drug Interactions. AAPS Workshop, September 2004. Click here to download PDF Immortalized Human Hepatocytes, XenoTech LLC 2004 Technology Guide. Click here to download PDF Steen, D. Immortalized Human Hepatocytes: A New Advance in Convenience and Performance. Current Separations 20(4) Bioanalytical Systems, pp137-139, 2004. Click here to download PDF Jessica B. Mills, Kelly A. Rose, Nalini Sadagopan, Jasminder Sahi, and Sonia M. F. de Morais. Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line. J Pharmacol Exp Ther.: 309(1):303-9. Epub 2004 Jan 13. Click here to download PDF A.L. Morris, E. Awwal and K.B. Frank. In vitro induction of cytochrome P450s and drug transporters using the Fa2N-4 immortalized human hepatocyte line. Drug. Metab. Rev. 35: 125, 2003. Abstract 249. (Presented at the annual ISSX meeting, Providence, Rhode Island, October 2003). Xenotechniques, Immortalized hepatocytes: A new in vitro approach to enzyme induction studies. Vol. 1, No. 1, 2003. Click here to download PDF J.B. Mills, R. Faris, J. Liu, S. Cascio and S.M. de Morais SM. An HTS assay for induction of enzymes and transporters using a human hepatocyte clonal line and RNA detection. Drug. Metab. Rev. 34: 124, 2002. Abstract 248. (Presented at the annual ISSX meeting, Orlando, Florida, October 2002). Liu J, Jauregui HO, Faris RA, Santangini HA, Trenkler DM, Silva PG, Garcia KM. Growth and metabolic activity of immortalized porcine hepatocytes in extracorporeal hollow fiber liver assist devices. Artificial Organs 25 (7): 539-545, 2001. Cascio SM. Novel strategies for immortalization of human hepatocytes. Artificial Organs 25 (7): 529-538, 2001. Liu J, Jing P, Naik S, Santangini H, Trenkler D, Thompson N, Rifai, A, Chowdhury JR, Jauregui HO. Characterization and detoxification functions of a nontumorigenic immortalized hepatocyte cell line (HepLiu). Cell Transplantation 8:219-232, 1999. Liu J, Naik S, Santangini H, Trenkler D, Pan J, Jauregui HO. Cytokeratins vs specific functions in immortalized porcine hepatocytes. Hepatology 26:550A, 1997. Liu J, Naik S, Santangini H, Trenkler D, Wolf D, Jauregui HO. Comparison of immortalized porcine and rat hepatocytes. Hepatology 24:197A, 1996. Liu J, Naik S, Santangini H, Trenkler D, Chowdhury JR, Jauregui HO. Characterization of immortalized porcine hepatocytes. Hepatology 24:197A, 1996. Liu J, Naik S, Santangini H, Trenkler D, Jauregui HO. Morphology and P450 function of immortalized hepatocytes in monolayer and hollow fiber culture. Hepatology 24:198A, 1996.