Primary liver cancer is the world’s fifth most frequently diagnosed cancer and is the second leading cause of cancer death.
MCT-485 is a low molecular weight synthetic dsRNA with tumor cytolytic properties. The mechanism of action and properties of
- Induction of tumor cell death upon direct exposure, while normal cells are minimally responsive to this agent.
- Production of TNF-alpha by cancer cells resulting in amplified tumor cell death and a localized immune reaction that has the potential to spread and curb progression of metastatic cancer.
There are other agents in development that are directly delivered to tumors with such a two-pronged mechanism of action: oncolytic viruses, plasmids encoding biological response modifiers, or TNF-alpha expressed by various vectors. MCT-485 offers an easy to manufacture, low cost alternative, with a potentially improved therapeutic index.